The FYBER (Feed Your gut Bacteria morE fibeR) study is a nutrition research study that is recruiting participants. Our target participants are :
-Men & women (non-pregnant, non-lactating) aged 18-50
-Overweight & obese individuals (BMI 25-35), weight stable and not attempting to lose weight
-Minimally physically active
-Not following a restrictive diet (i.e vegan, vegetarian, gluten free, ketogenic, etc).
Some background about the study:
Obesity has been linked to low-grade inflammation throughout the body. This inflammation is thought to contribute to diseases like heart disease and diabetes. The microbes in our gut are thought to be a link between obesity and this inflammation. This is because people with more body fat also tend to have higher levels of a certain bacterial molecule. This molecule is known to trigger the immune system and cause inflammation.
Diet is one way we can change the type of microbes in our gut. By changing the gut make-up, we may be able to improve inflammation. Inflammation and diet have been studied in many different populations. What they found is that there is less inflammation as more fiber is eaten. Meanwhile, a diet high in fat and simple sugar promotes inflammation. We also know that fiber has a big impact on our gut microbes. Since fiber cannot be broken down by our bodies, it is a main food source for our gut microbes. When fiber is broken down by microbes, waste products called short-chain fatty acids [SCFA] are made. These SCFA have been shown to reduce inflammation. Therefore, it is thought that fiber changes the gut microbes so that more SCFA are produced, and this may then reduce inflammation and improve overall health
The purpose of the study:
The purpose of this study is to determine how different types of fiber supplements may impact our health. More specifically, we aim to determine the role of the gut microbiome in these health benefits.